| Title : (+\/-)-Dievodialetins A-G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr - Huang_2020_Phytochemistry_182_112597 |
| Author(s) : Huang GY , Cui H , Lu XY , Zhang LD , Ding XY , Wu JJ , Duan LX , Zhang SJ , Liu Z , Zhang RR |
| Ref : Phytochemistry , 182 :112597 , 2020 |
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Abstract :
Seven pairs of undescribed enantiomeric bis-coumarins, (+/-)-dievodialetins A-G, were separated from the roots of Evodia lepta Merr. Two coumarin nuclei were linked via a 1,4-dimethyl4-vinylcyclohexene moiety in (+/-)-dievodialetins C-G. The structures of the undescribed compounds, including their absolute configurations were elucidated by spectroscopic analyses, X-ray diffraction, and computational calculations. In the biosynthetic pathways, these bis-coumarins were presumably derived from the precursors demethylsuberosin and 3-(3-methylbut-2-enyl)umbelliferone via a [4 + 2] Diels-Alder reaction. Besides, all compounds exhibited neuroprotective effects by inhibiting acetylcholinesterase (AChE) activity with IC(50) values ranging from 7.3 to 12.1 nM and they also suppressed oxidative stress (MDA and SOD) and neuroinflammation (IL-1beta and IL-6). |
| PubMedSearch : Huang_2020_Phytochemistry_182_112597 |
| PubMedID: 33341030 |
Huang GY, Cui H, Lu XY, Zhang LD, Ding XY, Wu JJ, Duan LX, Zhang SJ, Liu Z, Zhang RR (2020)
(+\/-)-Dievodialetins A-G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr
Phytochemistry
182 :112597
Huang GY, Cui H, Lu XY, Zhang LD, Ding XY, Wu JJ, Duan LX, Zhang SJ, Liu Z, Zhang RR (2020)
Phytochemistry
182 :112597