| Title : New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors - Hulin_2005_Bioorg.Med.Chem.Lett_15_4770 |
| Author(s) : Hulin B , Cabral S , Lopaze MG , Van Volkenburg MA , Andrews KM , Parker JC |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :4770 , 2005 |
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Abstract :
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity. |
| PubMedSearch : Hulin_2005_Bioorg.Med.Chem.Lett_15_4770 |
| PubMedID: 16115768 |
Hulin B, Cabral S, Lopaze MG, Van Volkenburg MA, Andrews KM, Parker JC (2005)
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
15 :4770
Hulin B, Cabral S, Lopaze MG, Van Volkenburg MA, Andrews KM, Parker JC (2005)
Bioorganic & Medicinal Chemistry Lett
15 :4770