| Title : Localization and structure of the muscarinic receptor ligand binding site - Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| Author(s) : Hulme EC , Curtis CA , Wheatley M , Aitken A , Harris AC |
| Ref : Trends in Pharmacological Sciences , Suppl :22 , 1989 |
|
Abstract :
A conserved aspartic acid residue in transmembrane helix 3 of the muscarinic acetylcholine receptors is important in binding the headgroup of muscarinic ligands. This acidic amino acid probably points into a relatively hydrophilic cavity whose walls are formed by the amphipathic transmembrane helices of the receptor. Amino acid side chains within this cavity contribute to ligand binding. |
| PubMedSearch : Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| PubMedID: 2694518 |
Hulme EC, Curtis CA, Wheatley M, Aitken A, Harris AC (1989)
Localization and structure of the muscarinic receptor ligand binding site
Trends in Pharmacological Sciences
Suppl :22
Hulme EC, Curtis CA, Wheatley M, Aitken A, Harris AC (1989)
Trends in Pharmacological Sciences
Suppl :22