Huo_2022_Cost.Eff.Resour.Alloc_20_19

Reference

Title : Cost-effectiveness of pharmacological therapies for people with Alzheimer's disease and other dementias: a systematic review and meta-analysis - Huo_2022_Cost.Eff.Resour.Alloc_20_19
Author(s) : Huo Z , Lin J , Bat BKK , Chan TK , Yip BHK , Tsoi KKF
Ref : Cost Eff Resour Alloc , 20 :19 , 2022
Abstract :

OBJECTIVES: This study aims to synthesize the empirical economic evidence of pharmaceutical therapies for people with dementia. STUDY DESIGN: Systematic review and meta-analysis. Literature evaluating the costs and effects of drug therapies for dementia was indexed until December 2021. Quality of study was assessed using the Cochrane Risk of Bias Tool and Consensus on Health Economic Criteria list. Cost data were standardized to 2020 US dollars and analyzed from healthcare service and societal perspectives. Random-effects models were used to synthesize economic and clinical data, based on mean differences (MDs) and standardized MDs. RESULTS: Ten unique studies were identified from 11,771 records. Acetylcholinesterase inhibitors (AChEIs) and memantine improved dementia-related symptoms, alongside nonsignificant savings in societal cost (AChEIs: MD-2002 [- 4944 ~ 939]; memantine: MD-6322 [- 14355 ~ 1711]). Despite decreases in cost, antidepressants of mirtazapine and sertraline and second-generation antipsychotics were limited by their significant side effects on patients' cognitive and activity functions. Subgroup analysis indicated that the impacts of AChEIs on cost were affected by different analytical perspectives, follow-up periods, and participant age. CONCLUSIONS: AChEIs and memantine are cost-effective with improvements in dementia-related symptoms and trends of cost-savings. More empirical evidence with non-industrial sponsorships and rigorous design in different settings is warranted.

PubMedSearch : Huo_2022_Cost.Eff.Resour.Alloc_20_19
PubMedID: 35443684

Related information

Citations formats

Huo Z, Lin J, Bat BKK, Chan TK, Yip BHK, Tsoi KKF (2022)
Cost-effectiveness of pharmacological therapies for people with Alzheimer's disease and other dementias: a systematic review and meta-analysis
Cost Eff Resour Alloc 20 :19

Huo Z, Lin J, Bat BKK, Chan TK, Yip BHK, Tsoi KKF (2022)
Cost Eff Resour Alloc 20 :19