Husna_2023_Int.J.Mol.Sci_24_

Reference

Title : N-Methyl Costaricine and Costaricine, Two Potent Butyrylcholinesterase Inhibitors from Alseodaphne pendulifolia Gamb - Husna_2023_Int.J.Mol.Sci_24_
Author(s) : Husna Hasnan MH , Sivasothy Y , Khaw KY , Nafiah MA , Hazni H , Litaudon M , Wan Ruzali WA , Liew SY , Awang K
Ref : Int J Mol Sci , 24 : , 2023
Abstract :

Studies have been conducted over the last decade to identify secondary metabolites from plants, in particular those from the class of alkaloids, for the development of new anti-Alzheimer's disease (AD) drugs. The genus Alseodaphne, comprising a wide range of alkaloids, is a promising source for the discovery of new cholinesterase inhibitors, the first-line treatment for AD. With regard to this, a phytochemical investigation of the dichloromethane extract of the bark of A. pendulifolia Gamb. was conducted. Repeated column chromatography and preparative thin-layer chromatography led to the isolation of a new bisbenzylisoquinoline alkaloid, N-methyl costaricine (1), together with costaricine (2), hernagine (3), N-methyl hernagine (4), corydine (5), and oxohernagine (6). Their structures were elucidated by the 1D- and 2D-NMR techniques and LCMS-IT-TOF analysis. Compounds 1 and 2 were more-potent BChE inhibitors than galantamine with IC(50) values of 3.51 +/- 0.80 microM and 2.90 +/- 0.56 microM, respectively. The Lineweaver-Burk plots of compounds 1 and 2 indicated they were mixed-mode inhibitors. Compounds 1 and 2 have the potential to be employed as lead compounds for the development of new drugs or medicinal supplements to treat AD.

PubMedSearch : Husna_2023_Int.J.Mol.Sci_24_
PubMedID: 37445877

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Citations formats

Husna Hasnan MH, Sivasothy Y, Khaw KY, Nafiah MA, Hazni H, Litaudon M, Wan Ruzali WA, Liew SY, Awang K (2023)
N-Methyl Costaricine and Costaricine, Two Potent Butyrylcholinesterase Inhibitors from Alseodaphne pendulifolia Gamb
Int J Mol Sci 24 :

Husna Hasnan MH, Sivasothy Y, Khaw KY, Nafiah MA, Hazni H, Litaudon M, Wan Ruzali WA, Liew SY, Awang K (2023)
Int J Mol Sci 24 :