Hussein_2018_Pestic.Biochem.Physiol_152_29

Reference

Title : A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3beta-Nrf2 signaling pathway - Hussein_2018_Pestic.Biochem.Physiol_152_29
Author(s) : Hussein RM , Mohamed WR , Omar HA
Ref : Pestic Biochem Physiol , 152 :29 , 2018
Abstract :

Chlorpyrifos (CPF) is an agricultural pesticide and a potential food contaminant, which causes neurotoxicity. Here, we aimed at exploring the link between the repeated exposure to CPF and memory dysfunction in rats and the possible protective effect of kaempferol, a flavonoid with appreciable antioxidant and anti-inflammatory activities. Rats were divided into: Control group (received drug vehicles for 14days); CPF-treated group (received subcutaneous 18mg/kg BW of CPF daily for 14days and CPF+Kaempferol treated group (received the same CPF dose +21mg/kg BW of Kaempferol intraperitoneally for 14days. On the 14(th) day, Y-maze and novel target recognition behavioral tests were employed to evaluate memory deficits. 24h after the last dose of CPF, animals were sacrificed, and brain tissues were used for the determination of oxidative stress biomarkers and gene expression levels of GSK3beta and Nrf2. The results revealed that CPF-treated rats suffered from severe deterioration of spatial and non-spatial memory functions with low activities of antioxidant enzymes and acetylcholinesterase (AChE). The administration of kaempferol significantly protected against CPF-induced neuronal damage, increased the activities of antioxidant enzymes and AChE and induced a better performance in the behavioral tests. The protective effect of kaempferol was mediated through the inhibition of GSK3beta gene expression and the induction of Nrf2 expression in the brain tissues. In conclusion, the repeated exposure to CPF is associated with oxidative stress and memory deficits in rats. However, kaempferol administration effectively alleviated CPF- induced brain toxicity, possibly through the modulation of GSK3beta-Nrf2 signaling pathway.

PubMedSearch : Hussein_2018_Pestic.Biochem.Physiol_152_29
PubMedID: 30497708

Related information

Inhibitor Kaempferol

Citations formats

Hussein RM, Mohamed WR, Omar HA (2018)
A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3beta-Nrf2 signaling pathway
Pestic Biochem Physiol 152 :29

Hussein RM, Mohamed WR, Omar HA (2018)
Pestic Biochem Physiol 152 :29