Ibanez-Tallon_2002_Neuron_33_893

Reference

Title : Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1 - Ibanez-Tallon_2002_Neuron_33_893
Author(s) : Ibanez-Tallon I , Miwa JM , Wang HL , Adams NC , Crabtree GW , Sine SM , Heintz N
Ref : Neuron , 33 :893 , 2002
Abstract :

We previously identified lynx1 as a neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs. Here, we show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs. Single-channel recordings show that lynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances desensitization. Macroscopic recordings quantify the enhancement of desensitization onset by lynx1 and further show that it slows recovery from desensitization and increases the EC(50). These experiments establish that direct interaction of lynx1 with nAChRs can result in a novel type of functional modulation and suggest that prototoxins may play important roles in vivo by modulating functional properties of their cognate CNS receptors.

PubMedSearch : Ibanez-Tallon_2002_Neuron_33_893
PubMedID: 11906696

Related information

Citations formats

Ibanez-Tallon I, Miwa JM, Wang HL, Adams NC, Crabtree GW, Sine SM, Heintz N (2002)
Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
Neuron 33 :893

Ibanez-Tallon I, Miwa JM, Wang HL, Adams NC, Crabtree GW, Sine SM, Heintz N (2002)
Neuron 33 :893