| Title : Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein\/delta-catenin - Ide_1999_Biochem.Biophys.Res.Commun_256_456 |
| Author(s) : Ide N , Hata Y , Deguchi M , Hirao K , Yao I , Takai Y |
| Ref : Biochemical & Biophysical Research Communications , 256 :456 , 1999 |
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Abstract :
Synaptic scaffolding molecule (S-SCAM) is a multiple PDZ domain-containing protein, which interacts with neuroligin, a cell adhesion molecule, and the NMDA receptor. In this study, we searched for S-SCAM-interacting proteins and obtained a neuralplakophilin-related armadillo-repeat protein (NPRAP)/delta-catenin. NPRAP/delta-catenin bound to the last PDZ domain of S-SCAM via its carboxyl-terminus in three different cell-free assay systems, was coimmunoprecipitated with S-SCAM from rat crude synaptosomes, and was localized at the excitatory synapses in rat hippocampal neurons. NPRAP/delta-catenin may be implicated in the molecular organization of synaptic junctions through the interaction with S-SCAM. |
| PubMedSearch : Ide_1999_Biochem.Biophys.Res.Commun_256_456 |
| PubMedID: 10080919 |
Ide N, Hata Y, Deguchi M, Hirao K, Yao I, Takai Y (1999)
Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein\/delta-catenin
Biochemical & Biophysical Research Communications
256 :456
Ide N, Hata Y, Deguchi M, Hirao K, Yao I, Takai Y (1999)
Biochemical & Biophysical Research Communications
256 :456