Ikari_1995_Neuroreport_6_481

Reference

Title : Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase - Ikari_1995_Neuroreport_6_481
Author(s) : Ikari H , Spangler EL , Greig NH , Pei XF , Brossi A , Speer D , Patel N , Ingram DK
Ref : Neuroreport , 6 :481 , 1995
Abstract :

A new generation of cholinesterase inhibitors is expected to overcome some limitations of the therapeutic use of anticholinesterases. Phenserine is a long-acting and selective inhibitor of acetylcholinesterase with a preferential brain uptake. We have assessed the effects of chronic phenserine tartrate treatment on performance of aged Fischer-344 rats in the 14-unit T-maze. Phenserine (1-3 mg kg-1, i.p.) treatment for 5 days significantly reduced the number of errors made in the Stone maze. Other performance variables were also improved. No side effects were noted across 5 days treatment at doses of 1-2 mg kg-1. Phenserine can therefore improve the performance of aged rats in this complex maze task without producing obvious side effects.

PubMedSearch : Ikari_1995_Neuroreport_6_481
PubMedID: 7766848

Related information

Inhibitor Phenserine

Citations formats

Ikari H, Spangler EL, Greig NH, Pei XF, Brossi A, Speer D, Patel N, Ingram DK (1995)
Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase
Neuroreport 6 :481

Ikari H, Spangler EL, Greig NH, Pei XF, Brossi A, Speer D, Patel N, Ingram DK (1995)
Neuroreport 6 :481