Inel_2026_Int.J.Pharm_693_126686

Immobilized lipase is widely used in biocatalysis, yet its potential in health remains underexplored. This review evaluates healthoriented applications of lipase immobilization, including advanced oral enzyme replacement systems for exocrine pancreatic insufficiency, coimmobilisation with probiotics to modulate gut ecology, and extracorporeal or implantable lipidremoval devices for acute dyslipidemia. Diagnostic applications in lipid biosensors, localized activation of esterbased prodrugs, and the enzymatic production of structured lipids for medical nutrition such as humanmilkfat mimetics and tailored triacylglycerols are also discussed. We emphasize how support materials and immobilization strategies govern catalytic activity, regiospecificity, stability and biocompatibility, and outline key translational challenges, including invivo validation, immune responses, process economics and regulatory issues.