| Title : First syntheses of (-)-tauranin and antibiotic (-)-BE-40644 based on lipase-catalyzed optical resolution of albicanol - Ishii_2009_Chem.Pharm.Bull.(Tokyo)_57_1103 |
| Author(s) : Ishii S , Fujii M , Akita H |
| Ref : Chem Pharm Bull (Tokyo) , 57 :1103 , 2009 |
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Abstract :
First syntheses of sesquiterpene quinones (-)-tauranin and (-)-BE-40644 which exhibited strong cytotoxicity against several cancer cell lines, were achieved from (8aS)-albicanol obtained by enzymatic optical resolution. By comparison of the sign of specific rotation between synthetic (12bS)-BE-40644 and natural (-)-BE-40644, the absolute configurations of natural (-)-BE-40644 were determined to be 4aS, 6aS, 12aR, 12bS. |
| PubMedSearch : Ishii_2009_Chem.Pharm.Bull.(Tokyo)_57_1103 |
| PubMedID: 19801866 |
Ishii S, Fujii M, Akita H (2009)
First syntheses of (-)-tauranin and antibiotic (-)-BE-40644 based on lipase-catalyzed optical resolution of albicanol
Chem Pharm Bull (Tokyo)
57 :1103
Ishii S, Fujii M, Akita H (2009)
Chem Pharm Bull (Tokyo)
57 :1103