| Title : cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells - Ishino_1998_J.Biochem.(Tokyo)_123_540 |
| Author(s) : Ishino T , Ohtsuki S , Homma K , Natori S |
| Ref : J Biochem (Tokyo) , 123 :540 , 1998 |
|
Abstract :
A cDNA for mouse prolyl endopeptidase (PEP) was cloned and its nucleotide sequence determined. The overall amino acid sequence identity between mouse and other mammalian PEPs was about 96%. A specific inhibitor of PEP, N-benzyloxycarbonyl-thioprolyl-thioprolinal- dimethylacetal (ZTTA), inhibited DNA synthesis by Swiss 3T3 cells. Mouse PEP was shown to be localized partly in restricted nuclear regions. These results suggest that PEP participates in mammalian DNA synthesis. |
| PubMedSearch : Ishino_1998_J.Biochem.(Tokyo)_123_540 |
| PubMedID: 9538240 |
| Gene_locus related to this paper: mouse-ppce |
| Gene_locus | mouse-ppce |
Ishino T, Ohtsuki S, Homma K, Natori S (1998)
cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells
J Biochem (Tokyo)
123 :540
Ishino T, Ohtsuki S, Homma K, Natori S (1998)
J Biochem (Tokyo)
123 :540