Ishola_2019_Brain.Res_1712_188

Reference

Title : Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling - Ishola_2019_Brain.Res_1712_188
Author(s) : Ishola IO , Osele MO , Chijioke MC , Adeyemi OO
Ref : Brain Research , 1712 :188 , 2019
Abstract :

Isorhamnetin (IRN), a 3'-O-methylated metabolite of quercetin has antioxidant, anti-inflammatory and neuroprotective properties. In this study, we investigated the learning and memory enhancing effects of IRN on spatial and non-spatial learning and memory deficits induced by scopolamine (3mg/kg, i.p; muscarinic antagonist) using the novel object recognition test (NORT) and Morris water maze (MWM) task. IRN (1, 5 or 50mg/kg, p.o.) or vehicle was administered to male albino for 3 consecutive days, scopolamine was given 1h after last administration on day 3. Five minutes post scopolamine administration the behavioural test of cognitive function was carried out. One hour after probe test (MWM task) on day 7, the brains were isolated to assay for oxidative stress, cholinesterase activity and brain derived neurotrophic factor (BDNF) levels in the prefrontal cortex (PFC) and hippocampus (HIPPO). IRN treatment significantly improved scopolamine-induced learning and memory impairment in behavioural tests. IRN reduced malondialdehyde and nitrite generation induced by scopolamine through increase in glutathione (GSH) level, superoxide dismutase (SOD) and catalase (CAT) activities in the prefrontal cortex and hippocampus. In addition, IRN attenuates scopolamine induced cholinesterase activity and BDNF level in the prefrontal cortex and hippocampus of mice. Findings from this study showed that IRN possesses cognition and memory enhancing properties possibly through enhancement of antioxidant defense system, cholinergic signaling and synaptic plasticity.

PubMedSearch : Ishola_2019_Brain.Res_1712_188
PubMedID: 30772273

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Citations formats

Ishola IO, Osele MO, Chijioke MC, Adeyemi OO (2019)
Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling
Brain Research 1712 :188

Ishola IO, Osele MO, Chijioke MC, Adeyemi OO (2019)
Brain Research 1712 :188