Ismail_2017_J.Toxicol.Environ.Health.A__1

Reference

Title : The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators - Ismail_2017_J.Toxicol.Environ.Health.A__1
Author(s) : Ismail AA , Wang K , Olson JR , Bonner MR , Hendy O , Rasoul GA , Rohlman DS
Ref : J Toxicol Environ Health A , :1 , 2017
Abstract :

Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.

PubMedSearch : Ismail_2017_J.Toxicol.Environ.Health.A__1
PubMedID: 28880741

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Citations formats

Ismail AA, Wang K, Olson JR, Bonner MR, Hendy O, Rasoul GA, Rohlman DS (2017)
The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators
J Toxicol Environ Health A :1

Ismail AA, Wang K, Olson JR, Bonner MR, Hendy O, Rasoul GA, Rohlman DS (2017)
J Toxicol Environ Health A :1