| Title : Patients achieving clearance of HCV with interferon therapy recover from decreased retinol-binding protein 4 levels - Iwasa_2009_J.Viral.Hepat_16_716 |
| Author(s) : Iwasa M , Hara N , Miyachi H , Tanaka H , Takeo M , Fujita N , Kobayashi Y , Kojima Y , Kaito M , Takei Y |
| Ref : J Viral Hepat , 16 :716 , 2009 |
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Abstract :
Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the blood in several insulin-resistant states. We investigated the association between plasma RBP4 and histological and biochemical characteristics of chronic hepatitis C (CHC), as well as changes in RBP4 levels following interferon therapy. Eighty-one patients with CHC infected with genotype 1 received treatment with peginterferon plus ribavirin. Histological data were available for 41 out of 81 patients before treatment, and the degree of fibrosis, inflammation and steatosis was assessed. Plasma levels of RBP4 were determined in serial samples (before, at the end of treatment, and at 6 months post-treatment). RBP4 levels were lower in CHC patients than in control subjects (34.6 +/- 12.3 microg/mL vs 46.2 +/- 10.5 microg/mL; P |
| PubMedSearch : Iwasa_2009_J.Viral.Hepat_16_716 |
| PubMedID: 19302338 |
Iwasa M, Hara N, Miyachi H, Tanaka H, Takeo M, Fujita N, Kobayashi Y, Kojima Y, Kaito M, Takei Y (2009)
Patients achieving clearance of HCV with interferon therapy recover from decreased retinol-binding protein 4 levels
J Viral Hepat
16 :716
Iwasa M, Hara N, Miyachi H, Tanaka H, Takeo M, Fujita N, Kobayashi Y, Kojima Y, Kaito M, Takei Y (2009)
J Viral Hepat
16 :716