Jabeen_2014_Eur.J.Med.Chem_80C_228

Reference

Title : Dual inhibition of the alpha-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis - Jabeen_2014_Eur.J.Med.Chem_80C_228
Author(s) : Jabeen F , Oliferenko PV , Oliferenko AA , Pillai GG , Ansari FL , Hall CD , Katritzky AR
Ref : Eur Journal of Medicinal Chemistry , 80C :228 , 2014
Abstract :

A striking dual inhibition of enzymes alpha-glucosidase and butyrylcholinesterase by small drug-like molecules, including 1,4-disubstituted-1,2,3-triazoles, chalcones, and benzothiazepines, was rationalized with the help of Molecular Field Topology Analysis, a 3D QSAR technique similar to CoMFA. A common pharmacophore supported the concept of a link existing between type-2 diabetes mellitus and Alzheimer's disease. These findings will be instrumental for rational design of drug candidates for both of these conditions.

PubMedSearch : Jabeen_2014_Eur.J.Med.Chem_80C_228
PubMedID: 24780600

Related information

Citations formats

Jabeen F, Oliferenko PV, Oliferenko AA, Pillai GG, Ansari FL, Hall CD, Katritzky AR (2014)
Dual inhibition of the alpha-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis
Eur Journal of Medicinal Chemistry 80C :228

Jabeen F, Oliferenko PV, Oliferenko AA, Pillai GG, Ansari FL, Hall CD, Katritzky AR (2014)
Eur Journal of Medicinal Chemistry 80C :228