| Title : The orthorhombic pseudopolymorph of tacrine hydrochloride - Jacobs_2016_Acta.Crystallogr.B.Struct.Sci.Cryst.Eng.Mater_72_771 |
| Author(s) : Jacobs J , Moris M , De Samber T , Vrijdag J , De Borggraeve W , Van Meervelt L |
| Ref : Acta Crystallographica B Struct Sci Cryst Eng Mater , 72 :771 , 2016 |
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Abstract :
Crystallization of tacrine hydrochloride, an acetylcholinesterase inhibitor used during treatment of mild to moderate Alzheimer's disease, from a water:ethanol solution has resulted in an orthorhombic pseudopolymorph. This orthorhombic form which occurs as a dihydrate shows columns of stacking acridines together with continuous Cl-Owater-Owater-Cl chains and ladder-like ribbons composed of squares and hexagons. |
| PubMedSearch : Jacobs_2016_Acta.Crystallogr.B.Struct.Sci.Cryst.Eng.Mater_72_771 |
| PubMedID: 27698319 |
Jacobs J, Moris M, De Samber T, Vrijdag J, De Borggraeve W, Van Meervelt L (2016)
The orthorhombic pseudopolymorph of tacrine hydrochloride
Acta Crystallographica B Struct Sci Cryst Eng Mater
72 :771
Jacobs J, Moris M, De Samber T, Vrijdag J, De Borggraeve W, Van Meervelt L (2016)
Acta Crystallographica B Struct Sci Cryst Eng Mater
72 :771