Jadhav_2009_J.Biochem.Mol.Toxicol_23_9

Reference

Title : Evaluation of sublethal effects of dichlorvos upon Caenorhabditis elegans based on a set of end points of toxicity - Jadhav_2009_J.Biochem.Mol.Toxicol_23_9
Author(s) : Jadhav KB , Rajini PS
Ref : J Biochem Mol Toxicol , 23 :9 , 2009
Abstract :

The primary objective of this study was to examine a possible correlation among the three endpoints of toxicity, namely, stress gene expression (hsp16), feeding, and acetylcholinesterase (AChE) activity in transgenic C. elegans (hsp16-lacZ) exposed to sublethal concentrations of dichlorvos, an organophosphorus insecticide. Worms exposed to dichlorvos (at 5, 40, and 80 microM) exhibited a concentration-dependent inhibition in feeding with total cessation in feeding occurring beyond 4 h of exposure. Concomitantly, marked and dose-dependent inhibition (69%-90%) of AChE was also evident after 4 h of exposure. Induction of heat shock protein (Hsp) was evident after 4 h of exposure (as seen from quantitative analysis), although maximum expression of Hsp was evident only after 24 h of exposure (as evident from qualitative analysis). Interestingly, the Hsp induction was restricted only to the pharyngeal region. Significant correlation was discernible between the three evaluated end points suggesting their possible interrelated role in the physiological dysfunctions evoked by sublethal concentrations of dichlorvos.

PubMedSearch : Jadhav_2009_J.Biochem.Mol.Toxicol_23_9
PubMedID: 19202558

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Citations formats

Jadhav KB, Rajini PS (2009)
Evaluation of sublethal effects of dichlorvos upon Caenorhabditis elegans based on a set of end points of toxicity
J Biochem Mol Toxicol 23 :9

Jadhav KB, Rajini PS (2009)
J Biochem Mol Toxicol 23 :9