| Title : Activities of enzymes of acetyl-CoA and acetylcholine metabolism in SN56 hybrid cholinergic cell line differentiated by dibutyryl cyclic AMP and all-trans retinoic acid - Jankowska_1997_Folia.Neuropathol_35_247 |
| Author(s) : Jankowska A , Blusztajn JK , Szutowicz A |
| Ref : Folia Neuropathol , 35 :247 , 1997 |
|
Abstract :
Cholinergic hybrid mouse septal neurons SN56 were differentiated by separate and combined application of 0.001 mM all-trans-retinoic acid and 1 mM dibutyryl cAMP. Each of agents caused about twofold increase of choline acetyltransferase activity. These activatory effects were additive. Dibutyryl cAMP resulted in twofold increase of ATP-citrate lyase and acetylcholinesterase activities. Retinoic acid did not affect these enzyme activities but partially abolished activatory effects of dibutyryl cAMP. Pyruvate dehydrogenase and other enzymes of acetyl-CoA metabolism were not affected by this treatment. This work demonstrates that it is possible to rise cholinergic neurons of different expression of cholinergic and acetyl-CoA metabolism. |
| PubMedSearch : Jankowska_1997_Folia.Neuropathol_35_247 |
| PubMedID: 9833404 |
Jankowska A, Blusztajn JK, Szutowicz A (1997)
Activities of enzymes of acetyl-CoA and acetylcholine metabolism in SN56 hybrid cholinergic cell line differentiated by dibutyryl cyclic AMP and all-trans retinoic acid
Folia Neuropathol
35 :247
Jankowska A, Blusztajn JK, Szutowicz A (1997)
Folia Neuropathol
35 :247