| Title : Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors - Jarlebark_1996_Biochem.Biophys.Res.Commun_229_363 |
| Author(s) : Jarlebark L , Erlandsson M , Uri A , King BF , Ziganshin AU , Johansson C , Heilbronn E |
| Ref : Biochemical & Biophysical Research Communications , 229 :363 , 1996 |
|
Abstract :
The role of extracellular ATP in vivo and the various cellular responses mediated by P2 purinoceptors have not yet been fully elucidated, in part depending on the lack of subtype-specific high affinity antagonists. Here we describe the synthesis of a new class of compounds, peptidyl derivatives of adenosine 5'-carboxylic acid, among which some have inhibitory effects in certain P2 purinoceptor-carrying biological systems, e.g., glioma and smooth muscle cell lines and isolated smooth muscle tissue preparations from guinea pig vas deferens and urinary bladder. |
| PubMedSearch : Jarlebark_1996_Biochem.Biophys.Res.Commun_229_363 |
| PubMedID: 8954905 |
Jarlebark L, Erlandsson M, Uri A, King BF, Ziganshin AU, Johansson C, Heilbronn E (1996)
Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors
Biochemical & Biophysical Research Communications
229 :363
Jarlebark L, Erlandsson M, Uri A, King BF, Ziganshin AU, Johansson C, Heilbronn E (1996)
Biochemical & Biophysical Research Communications
229 :363