Jeon_2021_ACS.Appl.Mater.Interfaces__

Reference

Title : Neuroligin-1-Modified Electrodes for Specific Coupling with a Presynaptic Neuronal Membrane - Jeon_2021_ACS.Appl.Mater.Interfaces__
Author(s) : Jeon J , Yoon SH , Oh MA , Cho W , Kim JY , Shin CI , Kim EJ , Chung TD
Ref : ACS Appl Mater Interfaces , : , 2021
Abstract :

Coordination of synapses onto electrodes with high specificity and maintaining a stable and long-lasting interface have importance in the field of neural interfaces. One potential approach is to present ligands on the surface of electrodes that would be bound through a protein-protein interaction to specific areas of neuronal cells. Here, we functionalize electrode surfaces with genetically engineered neuroligin-1 protein and demonstrate the formation of a nascent presynaptic bouton upon binding to neurexin-1 beta on the presynaptic membrane of neurons. The resulting synaptically connected electrode shows an assembly of presynaptic proteins and comparable exocytosis kinetics to that of native synapses. Importantly, a neuroligin-1-induced synapse-electrode interface exhibits type specificity and structural robustness. We envision that the use of synaptic adhesion proteins in modified neural electrodes may lead to new approaches in the interfacing of neural circuity and electronics.

PubMedSearch : Jeon_2021_ACS.Appl.Mater.Interfaces__
PubMedID: 33909393

Related information

Citations formats

Jeon J, Yoon SH, Oh MA, Cho W, Kim JY, Shin CI, Kim EJ, Chung TD (2021)
Neuroligin-1-Modified Electrodes for Specific Coupling with a Presynaptic Neuronal Membrane
ACS Appl Mater Interfaces :

Jeon J, Yoon SH, Oh MA, Cho W, Kim JY, Shin CI, Kim EJ, Chung TD (2021)
ACS Appl Mater Interfaces :