Jeong_2017_Int.J.Mol.Sci_18_

Reference

Title : Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure - Jeong_2017_Int.J.Mol.Sci_18_
Author(s) : Jeong JH , Choi BY , Kho AR , Lee SH , Hong DK , Lee SY , Song HK , Choi HC , Suh SW
Ref : Int J Mol Sci , 18 : , 2017
Abstract :

Epileptic seizures are short episodes of abnormal brain electrical activity. Many survivors of severe epilepsy display delayed neuronal death and permanent cognitive impairment. Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer's disease. However, the role of donepezil in seizure-induced hippocampal injury remains untested. Temporal lobe epilepsy (TLE) was induced by intraperitoneal injection of pilocarpine (25 mg/kg). Donepezil (2.5 mg/kg/day) was administered by gavage in three different settings: (1) pretreatment for three days before the seizure; (2) for one week immediately after the seizure; and (3) for three weeks from three weeks after the seizure. We found that donepezil showed mixed effects on seizure-induced brain injury, which were dependent on the treatment schedule. Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation. Early treatment with donepezil for one week showed neither adverse nor beneficial effects; however, a treatment duration of three weeks starting three weeks after the seizure showed a significant reduction in neuronal death, oxidative injury, and microglia activation. In conclusion, donepezil has therapeutic effects when injected for three weeks after seizure activity subsides. Therefore, the present study suggests that the therapeutic use of donepezil for epilepsy patients requires a well-conceived strategy for administration.

PubMedSearch : Jeong_2017_Int.J.Mol.Sci_18_
PubMedID: 29099058

Related information

Citations formats

Jeong JH, Choi BY, Kho AR, Lee SH, Hong DK, Lee SY, Song HK, Choi HC, Suh SW (2017)
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure
Int J Mol Sci 18 :

Jeong JH, Choi BY, Kho AR, Lee SH, Hong DK, Lee SY, Song HK, Choi HC, Suh SW (2017)
Int J Mol Sci 18 :