| Title : Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities - Jia_2020_Cell_182_1328 |
| Author(s) : Jia N , Wang J , Shi W , Du L , Sun Y , Zhan W , Jiang JF , Wang Q , Zhang B , Ji P , Bell-Sakyi L , Cui XM , Yuan TT , Jiang BG , Yang WF , Lam TT , Chang QC , Ding SJ , Wang XJ , Zhu JG , Ruan XD , Zhao L , Wei JT , Ye RZ , Que TC , Du CH , Zhou YH , Cheng JX , Dai PF , Guo WB , Han XH , Huang EJ , Li LF , Wei W , Gao YC , Liu JZ , Shao HZ , Wang X , Wang CC , Yang TC , Huo QB , Li W , Chen HY , Chen SE , Zhou LG , Ni XB , Tian JH , Sheng Y , Liu T , Pan YS , Xia LY , Li J , Zhao F , Cao WC |
| Ref : Cell , 182 :1328 , 2020 |
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Abstract :
Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases. |
| PubMedSearch : Jia_2020_Cell_182_1328 |
| PubMedID: 32814014 |
| Gene_locus related to this paper: haelo-a0a9j6fts7 , haelo-a0a9j6fxl5 , haelo-a0a9j6g095 , haelo-a0a9j6g1l8 , haelo-a0a9j6gm82 , haelo-a0a9j6gxu8 , rhimp-a0a9j6d5u9 |
Jia N, Wang J, Shi W, Du L, Sun Y, Zhan W, Jiang JF, Wang Q, Zhang B, Ji P, Bell-Sakyi L, Cui XM, Yuan TT, Jiang BG, Yang WF, Lam TT, Chang QC, Ding SJ, Wang XJ, Zhu JG, Ruan XD, Zhao L, Wei JT, Ye RZ, Que TC, Du CH, Zhou YH, Cheng JX, Dai PF, Guo WB, Han XH, Huang EJ, Li LF, Wei W, Gao YC, Liu JZ, Shao HZ, Wang X, Wang CC, Yang TC, Huo QB, Li W, Chen HY, Chen SE, Zhou LG, Ni XB, Tian JH, Sheng Y, Liu T, Pan YS, Xia LY, Li J, Zhao F, Cao WC (2020)
Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities
Cell
182 :1328
Jia N, Wang J, Shi W, Du L, Sun Y, Zhan W, Jiang JF, Wang Q, Zhang B, Ji P, Bell-Sakyi L, Cui XM, Yuan TT, Jiang BG, Yang WF, Lam TT, Chang QC, Ding SJ, Wang XJ, Zhu JG, Ruan XD, Zhao L, Wei JT, Ye RZ, Que TC, Du CH, Zhou YH, Cheng JX, Dai PF, Guo WB, Han XH, Huang EJ, Li LF, Wei W, Gao YC, Liu JZ, Shao HZ, Wang X, Wang CC, Yang TC, Huo QB, Li W, Chen HY, Chen SE, Zhou LG, Ni XB, Tian JH, Sheng Y, Liu T, Pan YS, Xia LY, Li J, Zhao F, Cao WC (2020)
Cell
182 :1328