| Title : Design, synthesis, and biological evaluation of new territrem B analogues - Jiang_2005_Chem.Biodivers_2_557 |
| Author(s) : Jiang X , Ao L , Zhou C , Yang L , Zhang Q , Li H , Sun L , Wu X , Bai H , Zhao Y |
| Ref : Chem Biodivers , 2 :557 , 2005 |
|
Abstract :
Some 23 analogues of the potent acetylcholinesterase (AChE) inhibitor territrem B (1) were designed, synthesized, and tested for their biological activities. Some of the new synthetic derivatives exhibited IC50 values for AChE inhibition in the upper micromolar range. Molecular-modeling studies indicated that a planar conformation seems to be crucial for AChE inhibition. The two N-atoms of the piperazine moieties in 5o, 5p, and 5r might further enhance the inhibitory effects. The cytotoxicities of selected compounds against six human tumor cell lines were also determined. |
| PubMedSearch : Jiang_2005_Chem.Biodivers_2_557 |
| PubMedID: 17192004 |
Jiang X, Ao L, Zhou C, Yang L, Zhang Q, Li H, Sun L, Wu X, Bai H, Zhao Y (2005)
Design, synthesis, and biological evaluation of new territrem B analogues
Chem Biodivers
2 :557
Jiang X, Ao L, Zhou C, Yang L, Zhang Q, Li H, Sun L, Wu X, Bai H, Zhao Y (2005)
Chem Biodivers
2 :557