Title : A specific molecular beacon probe for the detection of human prostate cancer cells - Jiang_2012_Bioorg.Med.Chem.Lett_22_3632 |
Author(s) : Jiang YL , McGoldrick CA , Yin D , Zhao J , Patel V , Brannon MF , Lightner JW , Krishnan K , Stone WL |
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :3632 , 2012 |
Abstract :
The small-molecule, water-soluble molecular beacon probe 1 is hydrolyzed by the lysate and living cells of human prostate cancer cell lines (LNCaP), resulting in strong green fluorescence. In contrast, probe 1 does not undergo significant hydrolysis in either the lysate or living cells of human nontumorigenic prostate cells (RWPE-1). These results, corroborated by UV-Vis spectroscopy and fluorescent microscopy, reveal that probe 1 is a sensitive and specific fluorogenic and chromogenic sensor for the detection of human prostate cancer cells among nontumorigenic prostate cells and that carboxylesterase activity is a specific biomarker for human prostate cancer cells. |
PubMedSearch : Jiang_2012_Bioorg.Med.Chem.Lett_22_3632 |
PubMedID: 22572577 |
Jiang YL, McGoldrick CA, Yin D, Zhao J, Patel V, Brannon MF, Lightner JW, Krishnan K, Stone WL (2012)
A specific molecular beacon probe for the detection of human prostate cancer cells
Bioorganic & Medicinal Chemistry Lett
22 :3632
Jiang YL, McGoldrick CA, Yin D, Zhao J, Patel V, Brannon MF, Lightner JW, Krishnan K, Stone WL (2012)
Bioorganic & Medicinal Chemistry Lett
22 :3632