| Title : Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum - Jiang_2015_Fitoterapia_109_155 |
| Author(s) : Jiang WW , Liu YC , Zhang ZJ , He J , Su J , Cheng X , Peng LY , Shao LD , Wu XD , Yang JH , Zhao QS |
| Ref : Fitoterapia , 109 :155 , 2015 |
|
Abstract :
Seven new fawcettimine-type (1-7) and two new lycopodine-type (8 and 9) Lycopodium alkaloids, as well as 10 known compounds, were isolated from the club moss, Lycopodium obscurum L. The structures of obscurumines H-P (1-9) were determined based on high-resolution MS and 1D and 2D NMR data. Compounds 1 and 2 include a new skeleton that is formed via the linkage of C-9-N-2', which is rarely present in Lycopodium alkaloids. The in vitro acetylcholinesterase (AChE) inhibitory activity assay showed that 5 exhibited weak anti-AChE activity with an IC50 value of 81.0muM. Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2muM. |
| PubMedSearch : Jiang_2015_Fitoterapia_109_155 |
| PubMedID: 26739385 |
Jiang WW, Liu YC, Zhang ZJ, He J, Su J, Cheng X, Peng LY, Shao LD, Wu XD, Yang JH, Zhao QS (2015)
Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
Fitoterapia
109 :155
Jiang WW, Liu YC, Zhang ZJ, He J, Su J, Cheng X, Peng LY, Shao LD, Wu XD, Yang JH, Zhao QS (2015)
Fitoterapia
109 :155