Jin_2014_Bioorg.Med.Chem.Lett_24_674

Reference

Title : Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for alpha4beta2alpha5 nicotinic acetylcholine receptors - Jin_2014_Bioorg.Med.Chem.Lett_24_674
Author(s) : Jin Z , Khan P , Shin Y , Wang J , Lin L , Cameron MD , Lindstrom JM , Kenny PJ , Kamenecka TM
Ref : Bioorganic & Medicinal Chemistry Lett , 24 :674 , 2014
Abstract :

The design and synthesis of a series of substituted heteroaromatic alpha4beta2alpha5 positive allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogues, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile (5k) and 3,3'-(2H-tetrazole-2,5-diyl)dipyridine (12h) with good in vitro efficacy were discovered.

PubMedSearch : Jin_2014_Bioorg.Med.Chem.Lett_24_674
PubMedID: 24365158

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Citations formats

Jin Z, Khan P, Shin Y, Wang J, Lin L, Cameron MD, Lindstrom JM, Kenny PJ, Kamenecka TM (2014)
Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for alpha4beta2alpha5 nicotinic acetylcholine receptors
Bioorganic & Medicinal Chemistry Lett 24 :674

Jin Z, Khan P, Shin Y, Wang J, Lin L, Cameron MD, Lindstrom JM, Kenny PJ, Kamenecka TM (2014)
Bioorganic & Medicinal Chemistry Lett 24 :674