| Title : Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta - Jing_2013_Chem.Biol.Interact_203_309 |
| Author(s) : Jing P , Zhang JY , Ouyang Q , Wu J , Zhang XJ |
| Ref : Chemico-Biological Interactions , 203 :309 , 2013 |
| Abstract : Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Lithium is also a potent inhibitor of glycogen synthase kinase-3beta (GSK3beta) activity, which is linked to Alzheimer's disease (AD). In experiments with cultured HEK293T cells, we show here that GSK3beta stabilizes synaptic acetylcholinesterase (AChE-S), a critical component of AD development. Cells treated with lithium exhibited rapid proteasomal degradation of AChE-S. Furthermore treatment of the cells with MG132, an inhibitor of the 26S proteasome, prevented the destabilizing effect of lithium on AChE-S. Taken together, these findings suggest that regulation of AChE-S protein stability may be an important biological target of lithium therapy. |
| ESTHER : Jing_2013_Chem.Biol.Interact_203_309 |
| PubMedSearch : Jing_2013_Chem.Biol.Interact_203_309 |
| PubMedID: 22944069 |
Jing P, Zhang JY, Ouyang Q, Wu J, Zhang XJ (2013)
Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta
Chemico-Biological Interactions
203 :309
Jing P, Zhang JY, Ouyang Q, Wu J, Zhang XJ (2013)
Chemico-Biological Interactions
203 :309