Jones_2007_Neuropharmacol_53_197

Reference

Title : Targeting the cholinergic system as a therapeutic strategy for the treatment of pain - Jones_2007_Neuropharmacol_53_197
Author(s) : Jones PG , Dunlop J
Ref : Neuropharmacology , 53 :197 , 2007
Abstract :

Acetylcholine mediates its effects through both the nicotinic acetylcholine receptors (ligand-gated ion channels) and the G protein-coupled muscarinic receptors. It plays pivotal roles in a diverse array of physiological processes and its activity is controlled through enzymatic degradation by acetylcholinesterase. The effects of receptor agonists and enzyme inhibitors, collectively termed cholinomimetics, in antinociception/analgesia are well established. These compounds successfully inhibit pain signaling in both humans and animals and are efficacious in a number of different preclinical and clinical pain models, suggesting a broad therapeutic potential. In this review we examine and discuss the evidence for the therapeutic exploitation of the cholinergic system as an approach to treat pain.

PubMedSearch : Jones_2007_Neuropharmacol_53_197
PubMedID: 17543355

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Citations formats

Jones PG, Dunlop J (2007)
Targeting the cholinergic system as a therapeutic strategy for the treatment of pain
Neuropharmacology 53 :197

Jones PG, Dunlop J (2007)
Neuropharmacology 53 :197