Title : Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors - Jung_2010_Proc.Natl.Acad.Sci.U.S.A_107_4710 |
Author(s) : Jung SY , Kim J , Kwon OB , Jung JH , An K , Jeong AY , Lee CJ , Choi YB , Bailey CH , Kandel ER , Kim JH |
Ref : Proc Natl Acad Sci U S A , 107 :4710 , 2010 |
Abstract :
Despite considerable evidence for a critical role of neuroligin-1 in the specification of excitatory synapses, the cellular mechanisms and physiological roles of neuroligin-1 in mature neural circuits are poorly understood. In mutant mice deficient in neuroligin-1, or adult rats in which neuroligin-1 was depleted, we have found that neuroligin-1 stabilizes the NMDA receptors residing in the postsynaptic membrane of amygdala principal neurons, which allows for a normal range of NMDA receptor-mediated synaptic transmission. We observed marked decreases in NMDA receptor-mediated synaptic currents at afferent inputs to the amygdala of neuroligin-1 knockout mice. However, the knockout mice exhibited a significant impairment in spike-timing-dependent long-term potentiation (STD-LTP) at the thalamic but not the cortical inputs to the amygdala. Subsequent electrophysiological analyses indicated that STD-LTP in the cortical pathway is largely independent of activation of postsynaptic NMDA receptors. These findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors. |
PubMedSearch : Jung_2010_Proc.Natl.Acad.Sci.U.S.A_107_4710 |
PubMedID: 20176955 |
Jung SY, Kim J, Kwon OB, Jung JH, An K, Jeong AY, Lee CJ, Choi YB, Bailey CH, Kandel ER, Kim JH (2010)
Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors
Proc Natl Acad Sci U S A
107 :4710
Jung SY, Kim J, Kwon OB, Jung JH, An K, Jeong AY, Lee CJ, Choi YB, Bailey CH, Kandel ER, Kim JH (2010)
Proc Natl Acad Sci U S A
107 :4710