Title : Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against beta-secretase and cholinesterases - Jung_2016_J.Ethnopharmacol_191_152 |
Author(s) : Jung HA , Ali MY , Jung HJ , Jeong HO , Chung HY , Choi JS |
Ref : J Ethnopharmacol , 191 :152 , 2016 |
Abstract :
ETHNOPHARMACOLOGICAL RELEVANCE: Semen Cassiae has been traditionally used as an herbal remedy for liver, eye, and acute inflammatory diseases. Recent pharmacological reports have indicated that Cassiae semen has neuroprotective effects, attributable to its anti-inflammatory actions, in ischemic stroke and Alzheimer's disease (AD) models. AIM OF THE STUDY: The basic goal of this study was to evaluate the anti-AD activities of C. obtusifolia and its major constituents. Previously, the extract of C. obtusifolia seeds, was reported to have memory enhancing properties and anti-AD activity to ameliorate amyloid beta-induced synaptic dysfunction. However, the responsible components of C. obtusifolia seeds in an AD are currently still unknown. In this study, we investigated the inhibitory effects of C. obtusifolia and its constituents against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) enzyme activity. MATERIALS AND |
PubMedSearch : Jung_2016_J.Ethnopharmacol_191_152 |
PubMedID: 27321278 |
Jung HA, Ali MY, Jung HJ, Jeong HO, Chung HY, Choi JS (2016)
Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against beta-secretase and cholinesterases
J Ethnopharmacol
191 :152
Jung HA, Ali MY, Jung HJ, Jeong HO, Chung HY, Choi JS (2016)
J Ethnopharmacol
191 :152