Kadri_2018_Environ.Sci.Pollut.Res.Int_25_19555

Reference

Title : Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice - Kadri_2018_Environ.Sci.Pollut.Res.Int_25_19555
Author(s) : Kadri Y , Nciri R , Brahmi N , Saidi S , Harrath AH , Alwasel S , Aldahmash W , El Feki A , Allagui MS
Ref : Environ Sci Pollut Res Int , 25 :19555 , 2018
Abstract :

Cerium chloride (CeCl3) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl3, 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl3-treated mice. In addition, CeCl3 induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl3-treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl3-induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl3-damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl3-induced damage in the brain.

PubMedSearch : Kadri_2018_Environ.Sci.Pollut.Res.Int_25_19555
PubMedID: 29732511

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Citations formats

Kadri Y, Nciri R, Brahmi N, Saidi S, Harrath AH, Alwasel S, Aldahmash W, El Feki A, Allagui MS (2018)
Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice
Environ Sci Pollut Res Int 25 :19555

Kadri Y, Nciri R, Brahmi N, Saidi S, Harrath AH, Alwasel S, Aldahmash W, El Feki A, Allagui MS (2018)
Environ Sci Pollut Res Int 25 :19555