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Kaduszkiewicz_2004_Fortschr.Neurol.Psychiatr_72_557

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Title : [Doubtful evidence for the use of the cholinesterase inhibitor donepezil in patients with dementia--a systematic review] - Kaduszkiewicz_2004_Fortschr.Neurol.Psychiatr_72_557
Author(s) : Kaduszkiewicz H , Beck-Bornholdt HP , van den Bussche H , Zimmermann T
Ref : Fortschritte der Neurologie Psychiatrie , 72 :557 , 2004
Abstract :

OBJECTIVE: Objective of this systematic review is to determine the level of scientific evidence for the use of Donepezil in Alzheimer's Disease.
METHODS: Ten randomised controlled double-blind trials testing Donepezil versus Placebo were identified in MEDLINE and EMBASE. All ten trials were included in this systematic review. Following a detailed catalogue of criteria the methodological standard of the ten trials was assessed.
RESULTS: The authors of eight trials postulated statistically significant differences in favour of Donepezil. Unfortunately, the methodological standard of all studies was insufficient. The methodological shortcomings are discussed in detail. CONCLUSION: With regard to severe methodological deficiencies the evidence for the use of Donepezil in moderate to severe Alzheimer's Disease is lacking. But even if the trials had been conducted in a methodologically correct way the clinical relevance of the postulated positive results would have to be questioned.
PubMedSearch : Kaduszkiewicz_2004_Fortschr.Neurol.Psychiatr_72_557
PubMedID: 15472779

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Citations formats

Kaduszkiewicz H, Beck-Bornholdt HP, van den Bussche H, Zimmermann T (2004)
[Doubtful evidence for the use of the cholinesterase inhibitor donepezil in patients with dementia--a systematic review]
Fortschritte der Neurologie Psychiatrie 72 :557

Kaduszkiewicz H, Beck-Bornholdt HP, van den Bussche H, Zimmermann T (2004)
Fortschritte der Neurologie Psychiatrie 72 :557