| Title : Biosynthesis of 6-Hydroxymellein Requires a Collaborating Polyketide Synthase-like Enzyme - Kahlert_2021_Angew.Chem.Int.Ed.Engl_60_11423 |
| Author(s) : Kahlert L , Villanueva M , Cox RJ , Skellam EJ |
| Ref : Angew Chem Int Ed Engl , 60 :11423 , 2021 |
|
Abstract :
The polyketide synthase (PKS)-like protein TerB, consisting of inactive dehydratase, inactive C-methyltransferase, and functional ketoreductase domains collaborates with the iterative non reducing PKS TerA to produce 6-hydroxymellein, a key pathway intermediate during the biosynthesis of various fungal natural products. The catalytically inactive dehydratase domain of TerB appears to mediate productive interactions with TerA, demonstrating a new mode of trans-interaction between iterative PKS components. |
| PubMedSearch : Kahlert_2021_Angew.Chem.Int.Ed.Engl_60_11423 |
| PubMedID: 33661567 |
Kahlert L, Villanueva M, Cox RJ, Skellam EJ (2021)
Biosynthesis of 6-Hydroxymellein Requires a Collaborating Polyketide Synthase-like Enzyme
Angew Chem Int Ed Engl
60 :11423
Kahlert L, Villanueva M, Cox RJ, Skellam EJ (2021)
Angew Chem Int Ed Engl
60 :11423