| Title : Involvement of DPPIV\/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells - Kajiyama_2006_Ann.N.Y.Acad.Sci_1086_233 |
| Author(s) : Kajiyama H , Shibata K , Terauchi M , Ino K , Nawa A , Kikkawa F |
| Ref : Annals of the New York Academy of Sciences , 1086 :233 , 2006 |
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Abstract :
Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma. |
| PubMedSearch : Kajiyama_2006_Ann.N.Y.Acad.Sci_1086_233 |
| PubMedID: 17185520 |
Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F (2006)
Involvement of DPPIV\/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells
Annals of the New York Academy of Sciences
1086 :233
Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F (2006)
Annals of the New York Academy of Sciences
1086 :233