Kale_2025_Curr.Drug.Res.Rev_17_266

It is a known fact that Alzheimer's disease causes degeneration of the central nervous system, which progresses and causes memory loss as well as loss of cognition. For many years, extensive research has been undertaken to find out newer possibilities to fight this disease at a molecular level along with many long-standing and expensive clinical trials. Many scientific research programs have either been discarded or unsuccessful. However, the research has not stopped and in the process, many heterocyclic scaffolds have been tried to build up novel drug molecules to combat this disease. A literature survey reveals that many heterocycles have been explored and were found to be very useful in treating many neurodegenerative disorders, including Alzheimer's disease, Parkinsonism and a few more. This review explains the journey and highlights the various strategies to develop new anti-Alzheimer drug candidates. It is a concise and rigorous literature excerpt involving research findings on heterocyclic scaffolds for treating this disease.