Kameoka_1993_Science_261_466

Reference

Title : Direct association of adenosine deaminase with a T cell activation antigen, CD26 - Kameoka_1993_Science_261_466
Author(s) : Kameoka J , Tanaka T , Nojima Y , Schlossman SF , Morimoto C
Ref : Science , 261 :466 , 1993
Abstract : CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.
ESTHER : Kameoka_1993_Science_261_466
PubMedSearch : Kameoka_1993_Science_261_466
PubMedID: 8101391

Related information

Citations formats

Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (1993)
Direct association of adenosine deaminase with a T cell activation antigen, CD26
Science 261 :466

Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (1993)
Science 261 :466

Array
(
    [id] => 70912
    [paper] => Kameoka_1993_Science_261_466
    [author] => Kameoka J || Tanaka T || Nojima Y || Schlossman SF || Morimoto C
    [year] => 1993
    [title] => Direct association of adenosine deaminase with a T cell activation antigen, CD26
    [journal] => Science
    [volume] => 261
    [page] => 466
    [medline] => 8101391
    [abstract] => Kameoka_1993_Science_261_466
    [kin_reference] => 
    [mutation] => 
    [kinetic_parameter] => 
    [inhibitor] => 
    [kin_value] => 
    [substrate] => 
    [gene_locus] => Array
        (
        )

    [family] => DPP4N_Peptidase_S9
    [interact_gene_locus] => 
    [xenobiotic_sensitivity] => 
    [news] => 
    [likid_reference] => 
    [lip_reference] => 
    [gene_locus_frgt] => 
    [structure] => 
    [comment] => 
    [chemical] => 
    [arpigny_jaeger] => 
    [reactivator] => 
    [disease] => 
    [enzyme] => 
    [risk_factor] => 
    [tissue] => 
    [sub_tissue] => 
    [activity] => 
    [specific_activity] => 
    [disease_by_interaction] => 
    [abstract_text] => Array
        (
            [id] => 19000
            [longtext] => Kameoka_1993_Science_261_466
            [content] => CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.
        )

)