Title : The synthesis and nicotinic binding activity of (+\/-)-epiquinamide and (+\/-)-C(1)-epiepiquinamide - Kanakubo_2006_Bioorg.Med.Chem.Lett_16_4648 |
Author(s) : Kanakubo A , Gray D , Innocent N , Wonnacott S , Gallagher T |
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :4648 , 2006 |
Abstract :
The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [(3)H]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. |
PubMedSearch : Kanakubo_2006_Bioorg.Med.Chem.Lett_16_4648 |
PubMedID: 16784846 |
Kanakubo A, Gray D, Innocent N, Wonnacott S, Gallagher T (2006)
The synthesis and nicotinic binding activity of (+\/-)-epiquinamide and (+\/-)-C(1)-epiepiquinamide
Bioorganic & Medicinal Chemistry Lett
16 :4648
Kanakubo A, Gray D, Innocent N, Wonnacott S, Gallagher T (2006)
Bioorganic & Medicinal Chemistry Lett
16 :4648