Kang_2022_J.Med.Food__

Reference

Title : The Aqueous Extract of Humulus japonicus Ameliorates Cognitive Dysfunction in Alzheimer's Disease Models via Modulating the Cholinergic System - Kang_2022_J.Med.Food__
Author(s) : Kang CM , Bang JS , Park SY , Jung TW , Kim HC , Chung YH , Jeong JH
Ref : J Med Food , : , 2022
Abstract :

Humulus japonicus (HJ) is an herbal medicine, which has been reported as being antioxidative and anti-inflammatory. The present study aimed to investigate the effect of oral administration of HJ water extract (HJW) on cognitive function through the cholinergic system in Alzheimer's disease (AD) mouse models. Institute of Cancer Research mice injected with beta-amyloid (Abeta) (1-42) (i.c.v.) and APP/PS1 transgenic (TG) mice were orally administered with HJW at 500 mg/kg/day for 3 weeks. Abeta-injected mice and APP/PS1 TG mice showed cognitive dysfunction, which was evaluated by various behavioral tests. HJW treatment significantly attenuated memory impairments in Abeta-injected mice and APP/PS1 TG mice. Abeta injection decreased acetylcholine (ACh) concentrations and choline acetyltransferase (ChAT) activity, and increased acetylcholinesterase (AChE) activity. These cholinergic impairments were also found in APP/PS1 TG mice. HJW significantly attenuated cholinergic alterations in Abeta-injected mice and TG mice. In addition, HJW significantly decreased Abeta plaque deposition in the cerebral cortex and hippocampus of TG mice. Therefore, the present study demonstrated that HJW protected against AD-related memory impairments via enhancing the cholinergic system and inhibiting Abeta plaque deposition.

PubMedSearch : Kang_2022_J.Med.Food__
PubMedID: 36178947

Related information

Citations formats

Kang CM, Bang JS, Park SY, Jung TW, Kim HC, Chung YH, Jeong JH (2022)
The Aqueous Extract of Humulus japonicus Ameliorates Cognitive Dysfunction in Alzheimer's Disease Models via Modulating the Cholinergic System
J Med Food :

Kang CM, Bang JS, Park SY, Jung TW, Kim HC, Chung YH, Jeong JH (2022)
J Med Food :