| Title : TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons - Kato_1999_Neurosci.Lett_260_5 |
| Author(s) : Kato K , Hayako H , Ishihara Y , Marui S , Iwane M , Miyamoto M |
| Ref : Neuroscience Letters , 260 :5 , 1999 |
|
Abstract :
TAK-147, a potent acetylcholinesterase (AChE) inhibitor, potentiated choline acetyltransferase (ChAT) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an EC50 value of 4.47 nM. Donepezil, another potent AChE inhibitor, also increased ChAT activity although its potency was less than that of TAK-147. Other AChE inhibitors (rivastigmine, tacrine, physostigmine and neostigmine) showed no effect. The effects of TAK-147 were greater in the presence of NGF, suggesting a synergistic action of TAK-147 and NGF. TAK-147 and donepezil showed high affinity for sigma receptors, whereas tacrine and physostigmine did not. Haloperidol and ifenprodil, high-affinity sigma ligands, potently enhanced ChAT activity in the septal neurons. These results suggest that TAK-147 may have neurotrophic activity on central cholinergic neurons, not via AChE inhibition but possibly via an effect on tau receptors. |
| PubMedSearch : Kato_1999_Neurosci.Lett_260_5 |
| PubMedID: 10027686 |
| Inhibitor | TAK-147 |
Kato K, Hayako H, Ishihara Y, Marui S, Iwane M, Miyamoto M (1999)
TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons
Neuroscience Letters
260 :5
Kato K, Hayako H, Ishihara Y, Marui S, Iwane M, Miyamoto M (1999)
Neuroscience Letters
260 :5