| Title : Asymmetric Syntheses of 2-Substituted and 2,5-Disubstituted Pyrrolidines from (3S,5R,7aR)-5-(Benzotriazol-1-yl)-3-phenyl[2,1-b]oxazolopyrrolidine - Katritzky_1999_J.Org.Chem_64_1979 |
| Author(s) : Katritzky AR , Cui XL , Yang B , Steel PJ |
| Ref : J Org Chem , 64 :1979 , 1999 |
| Abstract : Benzotriazole, 2,5-dimethoxytetrahydrofuran, and (S)-phenylglycinol in one step gave 80% of (3S, 5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl-[2,1-b]oxazolopyrrolidine (6), whose crystal structure was confirmed by X-ray crystallography. Novel chiral pyrrolidine synthon 6 reacts with organosilicon (allyltrimethylsilanes and vinyloxytrimethylsilanes), organophosphorus, organozinc, and Grignard reagents to afford chiral 2-substituted and 2,5-disubstituted pyrrolidines. |
| ESTHER : Katritzky_1999_J.Org.Chem_64_1979 |
| PubMedSearch : Katritzky_1999_J.Org.Chem_64_1979 |
| PubMedID: 11674292 |
Katritzky AR, Cui XL, Yang B, Steel PJ (1999)
Asymmetric Syntheses of 2-Substituted and 2,5-Disubstituted Pyrrolidines from (3S,5R,7aR)-5-(Benzotriazol-1-yl)-3-phenyl[2,1-b]oxazolopyrrolidine
J Org Chem
64 :1979
Katritzky AR, Cui XL, Yang B, Steel PJ (1999)
J Org Chem
64 :1979