Kaushansky_1994_Nature_369_568

Reference

Title : Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin [see comments] - Kaushansky_1994_Nature_369_568
Author(s) : Kaushansky K , Lok S , Holly RD , Broudy VC , Lin N , Bailey MC , Forstrom JW , Buddle MM , Oort PJ , Hagen FS , et al.
Ref : Nature , 369 :568 , 1994
Abstract :

The development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal cells and polypeptide cytokines. Recently, characterization of c-Mpl, the receptor encoded by the proto-oncogene c-mpl, revealed structural homology with the haematopoietic cytokine receptor family, and its involvement in megakaryocyte development. We report here that the ligand for c-Mpl is relatively lineage specific, works both alone and synergistically with early acting cytokines to support megakaryocyte colony formation, and acts at a late stage of development to increase megakaryocyte size, polyploidization and expression of differentiation markers. In vivo, c-Mpl ligand stimulates platelet production by greatly expanding marrow and splenic megakaryocytes and their progenitors, and by shifting the distribution of megakaryocyte ploidy to higher values. Thus, as c-Mpl ligand has the expected characteristics of the major regulator of megakaryocyte development, we propose that it be termed thrombopoietin.

PubMedSearch : Kaushansky_1994_Nature_369_568
PubMedID: 8202159

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Citations formats

Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, et al. (1994)
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin [see comments]
Nature 369 :568

Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, et al. (1994)
Nature 369 :568