| Title : An efficient synthesis of optically active physostigmine from tryptophan via alkylative cyclization - Kawahara_2000_Org.Lett_2_675 |
| Author(s) : Kawahara M , Nishida A , Nakagawa M |
| Ref : Org Lett , 2 :675 , 2000 |
|
Abstract :
[reaction: see text] A new and efficient synthetic route to physostigmine is described. Corey-Kim reagent reacted with tryptamine or tryptophan carbamates to give 3a-(methylthiomethyl)hexahydropyrrolo[2,3-b]indole skeletons. Formal total synthesis of racemic and chiral physostigmine was accomplished in excellent overall yields, in short steps. |
| PubMedSearch : Kawahara_2000_Org.Lett_2_675 |
| PubMedID: 10814407 |
Kawahara M, Nishida A, Nakagawa M (2000)
An efficient synthesis of optically active physostigmine from tryptophan via alkylative cyclization
Org Lett
2 :675
Kawahara M, Nishida A, Nakagawa M (2000)
Org Lett
2 :675