Title : Dysproteinuria induced in rats by O,O,S-trimethyl phosphorothioate - Keadtisuke_1987_Toxicol.Lett_37_33 |
Author(s) : Keadtisuke S , Fukuto TR |
Ref : Toxicol Lett , 37 :33 , 1987 |
Abstract :
Administration of a single oral dose of 60 mg/kg O,O,S-trimethyl phosphorothioate (OOS-Me), a malathion impurity, resulted in a substantial increase in the amounts of amino acids along with a change in the nature of proteins excreted in the urine of treated rats. In contrast to control rats, a small increase in albumin and a small decrease in alpha 1-globulin were observed. However, alpha2-, beta- and gamma 1-globulin, which were not detected in the urine of control rats, were found in substantial amounts in the urine of OOS-Me-treated rats. These findings, coupled with observed increases in urinary glucose levels and consistent specific gravity readings of 1.01 even though treated rats were experiencing oliguria, provide evidence for OOS-Me-induced kidney tubule damage. |
PubMedSearch : Keadtisuke_1987_Toxicol.Lett_37_33 |
PubMedID: 3590228 |
Keadtisuke S, Fukuto TR (1987)
Dysproteinuria induced in rats by O,O,S-trimethyl phosphorothioate
Toxicol Lett
37 :33
Keadtisuke S, Fukuto TR (1987)
Toxicol Lett
37 :33