Kean_1986_J.Am.Coll.Nutr_5_253

Liver pseudocholinesterase PChE activity was significantly higher in genetically obese ob/ob mice than in lean littermates as early as 23 days after birth By cytochemical electron microscopy increased staining for PChE was observed in the rough endoplasmic reticulum of ob/ob mice Albino mice with different diets showed that high-protein diets produced the greatest increase in PChE activity in the liver compared to carbohydrate or high fat Mice fed a normal mouse diet ad lib had significantly higher liver PChE activity than those fed a restricted diet of 2 g of a normal mouse chow per day In albino mice liver PChE activity varied directly with the protein content in the diet These studies suggest that liver PChE induction is a function of the level of protein in the diet