Kelic_1993_J.Neurol.Sci_114_62

Recombinant interferon-gamma (IFN-gamma) caused a dose-dependent increase in the proliferation of myoblasts in cultures of rat skeletal muscles as determined by bromodeoxyuridine incorporation. As a result of this proliferation the number of myotubes increased in the cultures, while the fusion index was unchanged. In myotubes exposed to IFN-gamma there was a change in the distribution of nicotinic acetylcholine receptors (nAChR) as detected by binding of FITC-conjugated alpha-bungarotoxin with a significant decrease in the number of linear aggregates and an increase in diffusely distributed receptors.