Khan_2012_BMC.Complement.Altern.Med_12_219

ABSTRACT BACKGROUND Launaea procumbens is used in the treatment of oxidative stress and mental disorders The effects of Launaea procumbens methanolic extracts LPMEs i.e 100 and 200 LPME mg/kg body weight b.w on cognitive performance as well as on the activity of acetylcholinesterase and antioxidant enzymes in rat brain tissue homogenates were evaluated METHODS Thirty male Sprague--Dawley rats were divided equally into three groups Rats in group I control were given saline vehicle group II received LPME 100 mg/kg b.w p.o and group III were treated with LPME 200 mg/kg b.w p.o in dimethyl sulfoxide DMSO for 7 days Antioxidant potential was assessed by measuring the activity of the antioxidant enzymes superoxide dismutase SOD catalase CAT glutathione peroxidase GSHpx glutathione reductase GSR and glutathione-S-transferase GST as well as lipid peroxidation and glutathione GSH contents in brain tissue homogenates Activity of acetylcholinesterase AChE and cognitive performance were also assessed RESULTS LPME administration reduced the levels of lipid peroxidation products TBARS contents increased GSH levels and enhanced the activities of SOD CAT GSHpx GSR and GST AChE activity was reduced by LPME treatment compared with untreated controls CONCLUSION These findings suggested the significant impact of LPMEs on brain function These effects could be through the antioxidant effects of the bioactive constituents present in LPME.