Title : New Cholinesterase Inhibitory Constituents from Lonicera quinquelocularis - Khan_2014_PLoS.One_9_e94952 |
Author(s) : Khan D , Khan HU , Khan F , Khan S , Badshah S , Khan AS , Samad A , Ali F , Khan I , Muhammad N |
Ref : PLoS ONE , 9 :e94952 , 2014 |
Abstract :
A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4-ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50% inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 microM while the values obtained against BChE were 5.98 and 9.84 microM respectively. Compounds 2 and 4 showed weak inhibition profile. |
PubMedSearch : Khan_2014_PLoS.One_9_e94952 |
PubMedID: 24733024 |
Substrate | Dioctyl-phthalate |
Khan D, Khan HU, Khan F, Khan S, Badshah S, Khan AS, Samad A, Ali F, Khan I, Muhammad N (2014)
New Cholinesterase Inhibitory Constituents from Lonicera quinquelocularis
PLoS ONE
9 :e94952
Khan D, Khan HU, Khan F, Khan S, Badshah S, Khan AS, Samad A, Ali F, Khan I, Muhammad N (2014)
PLoS ONE
9 :e94952