| Title : Identification of novel benzothiazole-thiadiazole-based thiazolidinone derivative: in vitro and in silico approaches to develop promising anti-Alzheimer's agents - Khan_2024_Future.Med.Chem__1 |
| Author(s) : Khan S , Hussain R , Iqbal T , Khan Y , Jamal U , Darwish HW , Adnan M |
| Ref : Future Med Chem , :1 , 2024 |
|
Abstract :
Aim: The present study describes benzothiazole derived thiazolidinone based thiadiazole derivatives (1-16) as anti-Alzheimer agents. Materials & methods: Synthesis of benzothiazole derived thiazolidinone based thiadiazole derivatives was achieved using the benzothiazole bearing 2-amine moiety. These synthesized compounds were confirmed via spectroscopic techniques ((1)H NMR, (13)C NMR and HREI-MS). These compounds were biologically evaluated for their anti-Alzheimer potential. Binding interactions with proteins and drug likeness of the analogs were explored through molecular docking and ADMET analysis, respectively. In the novel series, compound-3 emerged as the most potent inhibitor when compared with other derivatives of the series. Conclusion: The present study provides potent anti-Alzheimer's agents that can be further optimized to discover novel anti-Alzheimer's drugs. |
| PubMedSearch : Khan_2024_Future.Med.Chem__1 |
| PubMedID: 38940467 |
Khan S, Hussain R, Iqbal T, Khan Y, Jamal U, Darwish HW, Adnan M (2024)
Identification of novel benzothiazole-thiadiazole-based thiazolidinone derivative: in vitro and in silico approaches to develop promising anti-Alzheimer's agents
Future Med Chem
:1
Khan S, Hussain R, Iqbal T, Khan Y, Jamal U, Darwish HW, Adnan M (2024)
Future Med Chem
:1