| Title : Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors - Khoobi_2013_Eur.J.Med.Chem_68C_260 |
| Author(s) : Khoobi M , Alipour M , Sakhteman A , Nadri H , Moradi A , Ghandi M , Emami S , Foroumadi A , Shafiee A |
| Ref : Eur Journal of Medicinal Chemistry , 68C :260 , 2013 |
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Abstract :
A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) inhibitors. The 1-(4-fluorobenzyl)pyridinium derivative 6g showed the most potent anti-AChE activity (IC50 value = 0.038 muM) and the highest AChE/BCHE selectivity (SI > 48). The docking study permitted us to rationalize the observed structure-affinity relationships and to detect possible binding modes. |
| PubMedSearch : Khoobi_2013_Eur.J.Med.Chem_68C_260 |
| PubMedID: 23988409 |
| Inhibitor | N-Benzylpyridinium |
Khoobi M, Alipour M, Sakhteman A, Nadri H, Moradi A, Ghandi M, Emami S, Foroumadi A, Shafiee A (2013)
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry
68C :260
Khoobi M, Alipour M, Sakhteman A, Nadri H, Moradi A, Ghandi M, Emami S, Foroumadi A, Shafiee A (2013)
Eur Journal of Medicinal Chemistry
68C :260